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Trimethoprim

Trimethoprim

Trimethoprim is an antibiotic used to treat bacterial infections, especially urinary tract infections (UTIs), bladder infections, and respiratory infections. It works by stopping bacteria from making the folic acid they need to grow. This helps your body fight off the infection faster. Trimethoprim is not effective against viral infections like colds or flu. Always use it under your doctor’s advice.
Category: Anti Bacterial
Medically Reviewed by – Alicia Harper, PharmD
Last Updated on 8 July 2026

What is Trimethoprim used for?

Trimethoprim is an antibiotic used to treat bacterial infections, especially urinary tract infections (UTIs), bladder infections, and respiratory infections. It works by stopping bacteria from making the folic acid they need to grow. This helps your body fight off the infection faster. Trimethoprim is not effective against viral infections like colds or flu. Always use it under your doctor’s advice.

How to take Trimethoprim

Take Trimethoprim exactly as prescribed by your doctor.

  • Swallow the tablet with a full glass of water.

  • You can take it with or without food, but it’s best to take it at the same time each day.

  • Finish the full course even if you feel better early — stopping too soon may cause the infection to return.

Dosage instructions

The dosage depends on your age, infection type, and medical condition.

  • For most adults, the usual dose is 100mg twice daily or 200mg once daily.

  • For children, the doctor will decide based on their weight.
    Do not increase or skip doses. If you miss one, take it as soon as you remember. Never double the dose to make up for it.

Side effects

Like all medicines, Trimethoprim may cause side effects.
Common side effects include:

  • Nausea or vomiting

  • Skin rash or itching

  • Headache

Serious but rare side effects:

  • Shortness of breath

  • Swelling of the face or tongue

  • Unusual bruising or sore throat
    If any serious effects occur, seek medical help right away.

Drug interactions

Trimethoprim can interact with several medicines.

  • Methotrexate: Increases the risk of side effects.

  • Phenytoin: May raise drug levels in your blood.

  • Warfarin: Can enhance bleeding risk.
    Avoid taking Trimethoprim with other folic acid blockers unless directed by your doctor. Always inform your healthcare provider about any prescription drugs, supplements, or herbal medicines you use.

Warnings

Use Trimethoprim only if prescribed.

  • Avoid it if you’re pregnant or breastfeeding, unless your doctor says it’s safe.

  • People with kidney or liver problems should take extra care.

  • Drink plenty of water while on this medicine to prevent kidney issues.
    If you develop a rash, fever, or signs of an allergic reaction, stop taking it and get medical help immediately.

Storage

Store Trimethoprim tablets at room temperature (below 25°C).

  • Keep it in a dry place, away from sunlight and moisture.

  • Do not store it in the bathroom.

  • Keep it out of reach of children and pets.
    Always check the expiry date before use and properly dispose of unused tablets.

FAQ’s

What foods to avoid when taking Trimethoprim?

Avoid foods high in folic acid, such as spinach, broccoli, and beans, as they may reduce the medicine’s effectiveness. Also, limit alcohol it can upset your stomach or make side effects worse. Drink plenty of water to stay hydrated while on treatment.

Can you use Trimethoprim for tooth infection?

Trimethoprim is mainly used for urinary or respiratory infections, not dental ones. It may not target the bacteria that cause tooth infections. For dental infections, your doctor may prescribe antibiotics like amoxicillin or metronidazole instead.

Is Trimethoprim a strong antibiotic?

Yes, Trimethoprim is a potent antibiotic against many bacteria causing urinary or bladder infections. However, its strength depends on the type of bacteria. Always take it only when prescribed to avoid antibiotic resistance.

How long does it take for Trimethoprim to work?

Trimethoprim usually starts working within 1 to 3 days. You may feel better after a few doses, but continue the full course to prevent the infection from returning. If symptoms don’t improve in five days, contact your doctor.

Is Trimethoprim tablets a prescription medication?

Yes. Trimethoprim tablets is a prescription medication. It should be taken only when prescribed by a licensed healthcare provider. Do not start, stop, or change the dose without medical advice.

Is Trimethoprim tablets available over the counter?

No. Trimethoprim tablets is not available over the counter. It is a prescription-only medicine, so it should be used only after a licensed healthcare provider confirms it is suitable for your condition and explains the correct dosage, precautions, and possible interactions.

Where can I buy Trimethoprim online at low price?

You can buy Trimethoprim online at low price from InternationalDrugMart. This trusted online pharmacy offers affordable rates, secure checkout, and reliable global shipping. Shop conveniently from home and get your treatment delivered to your doorstep. Save more on quality healthcare with InternationalDrugMart today.

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