Pregabalin vs Gabapentin
Pregabalin
Gabapentin
Brand names
Lyrica
Neurontin
Drug Class
Anticonvulsant, Neuropathic Pain Agent
Anticonvulsant, Neuropathic Pain Agent
Uses
Nerve pain (neuropathy), Fibromyalgia, Seizures (partial onset), Anxiety disorder (GAD)
Nerve pain (neuropathy), Seizures (partial onset), Postherpetic neuralgia
Mechanism of Action
Modulates calcium channels to reduce neurotransmitter release
Modulates calcium channels to reduce neurotransmitter release
Dosage Forms
Capsules, Oral Solution
Capsules, Tablets, Oral Solution
Starting Dose
75 mg twice daily
300 mg once daily
Maximum Dose
600 mg per day
3600 mg per day
Half-Life
6.3 hours
5–7 hours
Bioavailability
High and consistent (>90%)
Decreases with higher doses (60–70%)
Onset of Action
Faster onset (within a few days)
Slower onset (days to weeks)
Common Side Effects
Dizziness, drowsiness, dry mouth, weight gain
Dizziness, drowsiness, fatigue, ataxia
Pregnancy Category
C
C
Controlled Substance
Schedule V
Not a controlled substance
Cost
Typically higher
Typically lower
FDA Approval
2004
1993
Coupon code
Enter your email to unlock the Pregabalin coupon.
Coupon code
Enter your email to unlock the Gabapentin coupon.
Frequently Asked Questions
What is the difference between Pregabalin and Gabapentin?+
Both treat nerve pain and seizures, but Pregabalin is absorbed more predictably and acts faster, while Gabapentin is typically lower-cost and not a controlled substance.
Which is better for nerve pain — Pregabalin or Gabapentin?+
Both are effective. Pregabalin often works at lower doses with faster onset; Gabapentin may suit those wanting a non-controlled, lower-cost option. Your physician decides based on your situation.
Is Pregabalin stronger than Gabapentin?+
Pregabalin is more potent per milligram and has higher, more consistent bioavailability, so lower doses are typically needed.