International Drug Mart

How Long Does Naltrexone Stay In Your System

How Long Does Naltrexone Stay In Your System in a webp image
Dr. Andrés Paredes, PharmD
Medically Reviewed by
Dr. Andrés Paredes, PharmD
Last Updated On

When you start a journey that leads to recovery, knowing how the medicine can work is a big part of the process. When you are taking Naltrexone medication for managing alcohol or opioid cravings, you shall also wonder as to how long it can last in the body.

Understanding such help can stay safe and plan your daily routine with complete confidence. Whether you use the medicine in form or the long-acting shot, the timing shall matter for your health.

The Short Answer: Oral vs Injectable

The time Naltrexone medication can stay in the system can all depend mostly on how you take it. There are two main ways doctors shall prescribe this medication: oral tablets and extended-release injections.

For the oral tablet (usually 50mg), the medicine can all work quickly but also leaves the body quickly. Most people can find that the primary effects are gone in just 24 to 36 hours.

The injectable version (Vivitrol) is super different as it is designed to release the thing slowly. This can further shoot can also stay in the system for approx. 30 days, and traces may be found for up to two months.

Understanding the "Half-Life"

Scientists use a term known as "half-life" to further measure how long it can take for half of a drug to leave the blood. This can give a clear picture of the medicine's "staying power."

  • Oral Naltrexone: The elimination half-life of naltrexone is roughly about 4 hours. However, its active by product, 6-beta-naltrexol, can stay longer, with a half-life of approx. 13 hours.

  • Injectable Naltrexone: The half-life for the shot is much longer, lasting between 5 and 10 days.

As the oral version has a short life, most people need to take one pill every single day. This can help in keeping enough medicine in the blood to block cravings and prevent a "high" from other substances.

Factors That Change the Timeline

Not everyone processes medicine at the same speed. There are various personal factors that can make Naltrexone medicine stay in the system longer or shorter than the average person.

Liver and Kidney Health

Naltrexone medication is processed by the liver and removed by the kidneys. When these organs are not working well, the medication can simply hang around longer than expected.

Your Metabolism and Weight

People who are having fast metabolism can usually clear drugs out of the system more quickly. Body mass and even how much water you drink can play a small role in this process

Age Matters

As we get older, our bodies often slow down when it comes to processing medications. Older adults might find that Naltrexone stays in their system a bit longer than it does for younger people.

Why the Timing is Critical

The most important reason to know how long Naltrexone stays in your system is to avoid "precipitated withdrawal." This is a very uncomfortable and sudden reaction.

If you have opioids in your system and take Naltrexone, it will "kick" those opioids off your brain receptors. This causes immediate withdrawal symptoms like nausea, chills, and muscle aches.

Doctors usually require you to be "clean" from all opioids for 7 to 10 days before your first dose. This ensures the opioids are out of your system before the Naltrexone moves in.

How Long Does Naltrexone Stay In Your System in a webp image

Does Naltrexone Show Up on Drug Tests?

This is a common question for people who have jobs that require regular screening. The good news is that Naltrexone is not a controlled substance or a drug of abuse.

standard drug test panels or 10-panel drug tests look for things like THC, cocaine, or illegal opioids. They do not look for Naltrexone because it does not cause a "high" or lead to addiction.

However, if you are taking a specialized test, it is always best to be honest. Bringing your prescription bottle or a note from your doctor can clear up any confusion immediately.

Safety and Side Effects

Even though Naltrexone is very helpful, your body might need a little time to get used to it. common side effects of naltrexon are mild and go away after a week or two of regular use.

  • Common issues: You might feel a bit of nausea, get a headache, or feel extra tired.

  • Sleep changes: Some people find it harder to fall asleep or have very vivid dreams when they first start.

  • Serious signs: While rare, you should call a doctor if you notice dark urine or yellowing of the eyes, as these are signs of liver stress.

Always tell your doctor about every medicine you take, including vitamins. Some cough syrups or diarrhea medicines contain tiny amounts of opioids that Naltrexone might block.

The Road to Recovery

Naltrexone is a powerful tool, but it works best when it is part of a bigger plan. This usually includes talking to a counselor or joining a support group to help with the emotional side of recovery.

It does not "cure" addiction, but it provides a safety net. By blocking the good feelings of alcohol or drugs, it helps break the cycle of cravings and use.

By understanding how long medicine stays in your system, you can better manage your health. You are taking a brave step toward a healthier life, and being informed makes that path much smoother.

Medical disclaimer

This content is for general informational purposes only and is not a substitute for professional medical advice. Consult your doctor or pharmacist regarding your specific situation before making any decisions about Naltrexone or other medications.

Order prescription medicines onlineTrusted pharmacy – wide range of medications available
USE CODEIDMBLG30Save up to 30%